We have received notice of award from the NIH Centers for Biomedical Research Excellence (COBRE) for our project titled “Characterizing Pathogen-Mediated Production of Secondary Metabolites in the Human Aerodigestive Tract Microbiome”! This project has been funded as part of a Phase I COBRE that establishes the Oklahoma Center for Microbiome Research (OCMR)!
The long-term goal of this work is to develop novel therapeutics that are “microbiome safe” by determining how antibiotics and other bioactive secondary metabolites mediate interspecies interactions between commensal bacteria and pathogens in the human microbiome. The overall objectives for this research are to (i) assess how co-culture with niche-specific pathogens shapes secondary metabolism in commensal bacteria from the human aerodigestive tract (ADT) and (ii) isolate and identify secondary metabolites with antibiotic activity against pathogens.
Congratulations to everyone in the Stubbendieck lab for all of their hard work leading to this award! Please see the Press Release from Oklahoma State University for more information about the OCMR.